Enhancing face validity of mouse models of Alzheimer’s disease with natural genetic variation

Classical laboratory strains show limited genetic diversity and do not harness natural genetic variation. Mouse models relevant to Alzheimer’s disease (AD) have largely been developed using these classical laboratory strains, such as C57BL/6J (B6), and this has likely contributed to the failure of t...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Onos, Kristen D., Uyar, Asli, Keezer, Kelly J., Jackson, Harriet M., Preuss, Christoph, Acklin, Casey J., O’Rourke, Rita, Buchanan, Rebecca, Cossette, Travis L., Sukoff Rizzo, Stacey J., Soto, Ileana, Carter, Gregory W., Howell, Gareth R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6576791/
https://ncbi.nlm.nih.gov/pubmed/31150388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008155
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