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Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer’s disease
Genetic and genome-wide association studies suggest a central role for microglia in Alzheimer’s disease (AD). However, single-cell RNA sequencing (scRNA-seq) of microglia in mice, a key preclinical model, has shown mixed results regarding translatability to human studies. To address this, scRNA-seq...
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| Veröffentlicht in: | Cell Rep |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7937391/ https://ncbi.nlm.nih.gov/pubmed/33567283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108739 |
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