A map of transcriptional heterogeneity and regulatory variation in human microglia

Microglia, the tissue resident macrophages of the CNS, play critical roles in immune defence, development and homeostasis. However, isolating microglia from humans in large numbers is challenging. Here, we profiled gene expression variation in primary human microglia isolated from 141 patients under...

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Pubblicato in:Nat Genet
Autori principali: Young, Adam MH, Kumasaka, Natsuhiko, Calvert, Fiona, Hammond, Timothy R, Knights, Andrew, Panousis, Nikolaos, Park, Jun Sung, Schwartzentruber, Jeremy, Liu, Jimmy, Kundu, Kousik, Segel, Michael, Murphy, Natalia A, McMurran, Christopher E, Bulstrode, Harry, Correia, Jason, Budohoski, Karol P, Joannides, Alexis, Guilfoyle, Mathew R, Trivedi, Rikin, Kirollos, Ramez, Morris, Robert, Garnett, Matthew R, Timofeev, Ivan, Jalloh, Ibrahim, Holland, Katherine, Mannion, Richard, Mair, Richard, Watts, Colin, Price, Stephen J, Kirkpatrick, Peter J, Santarius, Thomas, Mountjoy, Edward, Ghoussaini, Maya, Soranzo, Nicole, Bayraktar, Omer A., Stevens, Beth, Hutchinson, Peter J, Franklin, Robin JM, Gaffney, Daniel J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610960/
https://ncbi.nlm.nih.gov/pubmed/34083789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00875-2
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