Enhancing face validity of mouse models of Alzheimer’s disease with natural genetic variation

Classical laboratory strains show limited genetic diversity and do not harness natural genetic variation. Mouse models relevant to Alzheimer’s disease (AD) have largely been developed using these classical laboratory strains, such as C57BL/6J (B6), and this has likely contributed to the failure of t...

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Опубликовано в: :PLoS Genet
Главные авторы: Onos, Kristen D., Uyar, Asli, Keezer, Kelly J., Jackson, Harriet M., Preuss, Christoph, Acklin, Casey J., O’Rourke, Rita, Buchanan, Rebecca, Cossette, Travis L., Sukoff Rizzo, Stacey J., Soto, Ileana, Carter, Gregory W., Howell, Gareth R.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6576791/
https://ncbi.nlm.nih.gov/pubmed/31150388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008155
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