VE-1902—A direct thrombin inhibitor with reversible covalent mechanism of action shows efficacy with reduced bleeding in rodent models of thrombosis

INTRODUCTION: High incidence of bleeding events remains a key risk for patients taking anticoagulants, especially those in need of long-term combination therapy with antiplatelet agents. As a consequence, patients may not receive clinically indicated combination antithrombotic therapy. Here, we repo...

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Bibliografiske detaljer
Udgivet i:Thromb Res
Main Authors: Sivaraja, Mohanram, Clemens, Daniel M., Sizikov, Sivan, Dash, Subhadra, Xu, Chengpei, Rienzo, Matthew, Yang, Bo, Ryan, Molly, Chattopadhyay, Madhuri, Igoudin, Lev, Chang, Stephanie S., Keutzer, Samuel, Zalicki, Piotr, Estiarte, M. Angels, Shiau, Timothy P., Short, Kevin M., Williams, David C., Datta, Anirban, Pozzi, Nicola, Di Cera, Enrico, Gibson, C. Michael, Fox, Keith A.A., Kita, David B.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936662/
https://ncbi.nlm.nih.gov/pubmed/32339947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2020.04.020
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