A neural m(6)A/Ythdf pathway is required for learning and memory in Drosophila

Epitranscriptomic modifications can impact behavior. Here, we used Drosophila melanogaster to study N(6)-methyladenosine (m(6)A), the most abundant modification of mRNA. Proteomic and functional analyses confirm its nuclear (Ythdc1) and cytoplasmic (Ythdf) YTH domain proteins as major m(6)A binders....

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Publicado en:Nat Commun
Main Authors: Kan, Lijuan, Ott, Stanislav, Joseph, Brian, Park, Eun Sil, Dai, Wei, Kleiner, Ralph E., Claridge-Chang, Adam, Lai, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935873/
https://ncbi.nlm.nih.gov/pubmed/33674589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21537-1
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