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A neural m(6)A/Ythdf pathway is required for learning and memory in Drosophila
Epitranscriptomic modifications can impact behavior. Here, we used Drosophila melanogaster to study N(6)-methyladenosine (m(6)A), the most abundant modification of mRNA. Proteomic and functional analyses confirm its nuclear (Ythdc1) and cytoplasmic (Ythdf) YTH domain proteins as major m(6)A binders....
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7935873/ https://ncbi.nlm.nih.gov/pubmed/33674589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21537-1 |
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