Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling

Previous work has suggested androgen receptor (AR) signaling mediates prostate cancer progression in part through the modulation of autophagy. However, clinical trials testing autophagy inhibition using chloroquine derivatives in men with castration-resistant prostate cancer (CRPC) have yet to yield...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Lin, Chenchu, Blessing, Alicia M., Pulliam, Thomas L., Shi, Yan, Wilkenfeld, Sandi R., Han, Jenny J., Murray, Mollianne M., Pham, Alexander H., Duong, Kevin, Brun, Sonja N., Shaw, Reuben J., Ittmann, Michael M., Frigo, Daniel E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935762/
https://ncbi.nlm.nih.gov/pubmed/33531625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01658-z
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