Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling

Previous work has suggested androgen receptor (AR) signaling mediates prostate cancer progression in part through the modulation of autophagy. However, clinical trials testing autophagy inhibition using chloroquine derivatives in men with castration-resistant prostate cancer (CRPC) have yet to yield...

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Pubblicato in:Oncogene
Autori principali: Lin, Chenchu, Blessing, Alicia M., Pulliam, Thomas L., Shi, Yan, Wilkenfeld, Sandi R., Han, Jenny J., Murray, Mollianne M., Pham, Alexander H., Duong, Kevin, Brun, Sonja N., Shaw, Reuben J., Ittmann, Michael M., Frigo, Daniel E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935762/
https://ncbi.nlm.nih.gov/pubmed/33531625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01658-z
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