Development and validation of an LC-MS/MS method for determination of hydroxychloroquine, its two metabolites, and azithromycin in EDTA-treated human plasma

BACKGROUND: Hydroxychloroquine (HCQ) and azithromycin (AZM) are antimalarial drugs recently reported to be active against severe acute respiratory syndrome coronavirus- 2 (SARS-CoV-2), which is causing the global COVID-19 pandemic. In an emergency response to the pandemic, we aimed to develop a quan...

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Vydáno v:PLoS One
Hlavní autoři: Sok, Vong, Marzan, Florence, Gingrich, David, Aweeka, Francesca, Huang, Liusheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935301/
https://ncbi.nlm.nih.gov/pubmed/33667247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0247356
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