A Therapeutic Strategy for Preferential Targeting of TET2-Mutant and TET Dioxygenase–Deficient Cells in Myeloid Neoplasms

TET2 is frequently mutated in myeloid neoplasms. Genetic TET2 deficiency leads to skewed myeloid differentiation and clonal expansion, but minimal residual TET activity is critical for survival of neoplastic progenitor and stem cells. Consistent with mutual exclusivity of TET2 and neomorphic IDH1/2...

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Detalhes bibliográficos
Publicado no:Blood Cancer Discov
Main Authors: Guan, Yihong, Tiwari, Anand D., Phillips, James G., Hasipek, Metis, Grabowski, Dale R., Pagliuca, Simona, Gopal, Priyanka, Kerr, Cassandra M., Adema, Vera, Radivoyevitch, Tomas, Parker, Yvonne, Lindner, Daniel J., Meggendorfer, Manja, Abazeed, Mohamed, Sekeres, Mikkeal A., Mian, Omar Y., Haferlach, Torsten, Maciejewski, Jaroslaw P., Jha, Babal K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for Cancer Research 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935131/
https://ncbi.nlm.nih.gov/pubmed/33681816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2643-3230.BCD-20-0173
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