Invariant phenotype and molecular association of biallelic TET2 mutant myeloid neoplasia

Somatic TET2 mutations (TET2(MT)) are frequent in myeloid neoplasia (MN), particularly chronic myelomonocytic leukemia (CMML). TET2(MT) includes mostly loss-of-function/hypomorphic hits. Impaired TET2 activity skews differentiation of hematopoietic stem cells toward proliferating myeloid precursors....

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood Adv
Egile Nagusiak: Awada, Hassan, Nagata, Yasunobu, Goyal, Abhinav, Asad, Mohammad F., Patel, Bhumika, Hirsch, Cassandra M., Kuzmanovic, Teodora, Guan, Yihong, Przychodzen, Bartlomiej P., Aly, Mai, Adema, Vera, Shen, Wenyi, Williams, Louis, Nazha, Aziz, Abazeed, Mohamed E., Sekeres, Mikkael A., Radivoyevitch, Tomas, Haferlach, Torsten, Jha, Babal K., Visconte, Valeria, Maciejewski, Jaroslaw P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2019
Gaiak:
Myeloid Neoplasia
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373752/
https://ncbi.nlm.nih.gov/pubmed/30709865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024216
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