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SAR Insights Into TET2 Catalytic Domain Inhibition: Synthesis of 2-Hydroxy-4-Methylene-pentanedicarboxylates
The TET enzyme family of Ten-Eleven Translocation methylcytosine (5mC) dioxygenases comprising 3 members, TET1–3, play key roles in DNA demethylation. These processes regulate transcription programs that determine cell lineage, survival, proliferation, and differentiation. The impetus for our invest...
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| Publié dans: | Bioorg Med Chem |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8171112/ https://ncbi.nlm.nih.gov/pubmed/33894507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2021.116141 |
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