A STAT3 inhibitor ameliorates CNS autoimmunity by restoring Teff:Treg balance

Reestablishing an appropriate balance between T effector cells (Teff) and Tregs is essential for correcting autoimmunity. Multiple sclerosis (MS) is an immune-mediated chronic CNS disease characterized by neuroinflammation, demyelination, and neuronal degeneration, in which the Teff:Treg balance is...

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Udgivet i:JCI Insight
Main Authors: Aqel, Saba I., Yang, Xiaozhi, Kraus, Emma E., Song, Jinhua, Farinas, Marissa F., Zhao, Erin Y., Pei, Wei, Lovett-Racke, Amy E., Racke, Michael K., Li, Chenglong, Yang, Yuhong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934926/
https://ncbi.nlm.nih.gov/pubmed/33411696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.142376
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