Regulation of effector function of CNS autoreactive CD4 T cells through inhibitory receptors and IL-7Rα

BACKGROUND: Multiple sclerosis (MS) is a chronic CNS autoimmune disease characterized by inflammation, demyelination, and neuronal degeneration, where myelin-specific CD4 T cells play critical roles in the formation of acute MS lesions and disease progression. The suppression of IL-7Rα expression an...

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Udgivet i:J Neuroinflammation
Main Authors: Nuro-Gyina, Patrick K, Rieser, Elizabeth L, Granitto, Marissa C, Pei, Wei, Liu, Yue, Lee, Priscilla W, Aqel, Saba, Zhang, Jian, Lovett-Racke, Amy E, Racke, Michael K, Yang, Yuhong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135771/
https://ncbi.nlm.nih.gov/pubmed/27912762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0768-3
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