Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer

BACKGROUND: Cancer immunotherapy can be potentiated by conditioning regimens such as cyclophosphamide, which reduces the level of regulatory T cells (tregs). However, myeloid suppressive cells are still remaining. Accordingly to previous reports, gemcitabine improves immune status of cancer patients...

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Veröffentlicht in:J Transl Med
Hauptverfasser: Eriksson, Emma, Wenthe, Jessica, Irenaeus, Sandra, Loskog, Angelica, Ullenhag, Gustav
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041438/
https://ncbi.nlm.nih.gov/pubmed/27687804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-1037-z
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