Local irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients

BACKGROUND: AdCD40L is an immunostimulatory gene therapy under evaluation for advanced melanoma, including ocular melanoma. Herein, we present the final data of a Phase I/IIa trial using AdCD40L alone or in combination with low dose cyclophosphamide +/- radiation therapy. METHODS: AdCD40L is a repli...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Irenaeus, Sandra, Schiza, Aglaia, Mangsbo, Sara M., Wenthe, Jessica, Eriksson, Emma, Krause, Johan, Sundin, Anders, Ahlström, Håkan, Tötterman, Thomas H., Loskog, Angelica, Ullenhag, Gustav J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5667983/
https://ncbi.nlm.nih.gov/pubmed/29108250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19750
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