Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

BACKGROUND AND AIMS: Malignant melanoma is an aggressive tumor sensitive for immunotherapy such as checkpoint blockade antibodies. Still, most patients with late stage disease do not respond, and the side effects can be severe. Stimulation of the CD40 pathway to initiate anti-tumor immunity is a pro...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Schiza, A., Wenthe, J., Mangsbo, S., Eriksson, E., Nilsson, Anders, Tötterman, T. H., Loskog, A., Ullenhag, G.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399418/
https://ncbi.nlm.nih.gov/pubmed/28427434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1182-z
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