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Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40

Multiple myeloma (MM) is a plasma cell malignancy that is characterized by immune dysregulation. MM is commonly treated with immunomodulating agents, but still remains incurable. Herein, we proposed and evaluated immunostimulatory Lokon oncolytic adenoviruses (LOAd) for MM treatment. LOAd viruses ar...

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Podrobná bibliografie
Vydáno v:Cancer Gene Ther
Hlavní autoři: Wenthe, Jessica, Naseri, Sedigheh, Hellström, Ann-Charlotte, Wiklund, Helena Jernberg, Eriksson, Emma, Loskog, Angelica
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group US 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725669/
https://ncbi.nlm.nih.gov/pubmed/32355275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41417-020-0176-9
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