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Exhausted-like CD8(+) T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects
Clinical trials of biologic therapies in type 1 diabetes (T1D) aim to mitigate autoimmune destruction of pancreatic β cells through immune perturbation and serve as resources to elucidate immunological mechanisms in health and disease. In the T1DAL trial of alefacept (LFA3-Ig) in recent-onset T1D, e...
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| Publié dans: | JCI Insight |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Clinical Investigation
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7934874/ https://ncbi.nlm.nih.gov/pubmed/33351781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.142680 |
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