Exhausted-like CD8(+) T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects

Clinical trials of biologic therapies in type 1 diabetes (T1D) aim to mitigate autoimmune destruction of pancreatic β cells through immune perturbation and serve as resources to elucidate immunological mechanisms in health and disease. In the T1DAL trial of alefacept (LFA3-Ig) in recent-onset T1D, e...

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Publicado en:JCI Insight
Autores principales: Diggins, Kirsten E., Serti, Elisavet, Muir, Virginia, Rosasco, Mario, Lu, TingTing, Balmas, Elisa, Nepom, Gerald, Long, S. Alice, Linsley, Peter S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2021
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934874/
https://ncbi.nlm.nih.gov/pubmed/33351781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.142680
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