Autoreactive CD8(+) T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

Although most patients with type 1 diabetes (T1D) retain some functional insulin-producing islet β cells at the time of diagnosis, the rate of further β cell loss varies across individuals. It is not clear what drives this differential progression rate. CD8(+) T cells have been implicated in the aut...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wiedeman, Alice E., Muir, Virginia S., Rosasco, Mario G., DeBerg, Hannah A., Presnell, Scott, Haas, Bertrand, Dufort, Matthew J., Speake, Cate, Greenbaum, Carla J., Serti, Elisavet, Nepom, Gerald T., Blahnik, Gabriele, Kus, Anna M., James, Eddie A., Linsley, Peter S., Long, S. Alice
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934185/
https://ncbi.nlm.nih.gov/pubmed/31815738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126595
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