Autoreactive CD8(+) T cell exhaustion distinguishes subjects with slow type 1 diabetes progression

Although most patients with type 1 diabetes (T1D) retain some functional insulin-producing islet β cells at the time of diagnosis, the rate of further β cell loss varies across individuals. It is not clear what drives this differential progression rate. CD8(+) T cells have been implicated in the aut...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Wiedeman, Alice E., Muir, Virginia S., Rosasco, Mario G., DeBerg, Hannah A., Presnell, Scott, Haas, Bertrand, Dufort, Matthew J., Speake, Cate, Greenbaum, Carla J., Serti, Elisavet, Nepom, Gerald T., Blahnik, Gabriele, Kus, Anna M., James, Eddie A., Linsley, Peter S., Long, S. Alice
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934185/
https://ncbi.nlm.nih.gov/pubmed/31815738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI126595
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