The longevity gene mIndy (I’m Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms

Reduced expression of the plasma membrane citrate transporter INDY (acronym I’m Not Dead, Yet) extends life span in lower organisms. Deletion of the mammalian Indy (mIndy) gene in rodents improves metabolism via mechanisms akin to caloric restriction, known to lower blood pressure (BP) by sympathoad...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Willmes, Diana M., Daniels, Martin, Kurzbach, Anica, Lieske, Stefanie, Bechmann, Nicole, Schumann, Tina, Henke, Christine, El-Agroudy, Nermeen N., Da Costa Goncalves, Andrey C., Peitzsch, Mirko, Hofmann, Anja, Kanczkowski, Waldemar, Kräker, Kristin, Müller, Dominik N., Morawietz, Henning, Deussen, Andreas, Wagner, Michael, El-Armouche, Ali, Helfand, Stephen L., Bornstein, Stephan R., de Cabo, Rafael, Bernier, Michel, Eisenhofer, Graeme, Tank, Jens, Jordan, Jens, Birkenfeld, Andreas L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934862/
https://ncbi.nlm.nih.gov/pubmed/33491666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136083
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