The longevity gene mIndy (I’m Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms

Reduced expression of the plasma membrane citrate transporter INDY (acronym I’m Not Dead, Yet) extends life span in lower organisms. Deletion of the mammalian Indy (mIndy) gene in rodents improves metabolism via mechanisms akin to caloric restriction, known to lower blood pressure (BP) by sympathoad...

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Bibliografiset tiedot
Julkaisussa:JCI Insight
Päätekijät: Willmes, Diana M., Daniels, Martin, Kurzbach, Anica, Lieske, Stefanie, Bechmann, Nicole, Schumann, Tina, Henke, Christine, El-Agroudy, Nermeen N., Da Costa Goncalves, Andrey C., Peitzsch, Mirko, Hofmann, Anja, Kanczkowski, Waldemar, Kräker, Kristin, Müller, Dominik N., Morawietz, Henning, Deussen, Andreas, Wagner, Michael, El-Armouche, Ali, Helfand, Stephen L., Bornstein, Stephan R., de Cabo, Rafael, Bernier, Michel, Eisenhofer, Graeme, Tank, Jens, Jordan, Jens, Birkenfeld, Andreas L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2021
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Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7934862/
https://ncbi.nlm.nih.gov/pubmed/33491666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136083
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