Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice

OBJECTIVE: Non-alcoholic fatty liver disease is a world-wide health concern and risk factor for cardio-metabolic diseases. Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotransporter solute carrier family 13 member 5 (SLC13A5,...

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Vydáno v:Mol Metab
Hlavní autoři: Brachs, Sebastian, Winkel, Angelika F., Tang, Hui, Birkenfeld, Andreas L., Brunner, Bodo, Jahn-Hofmann, Kerstin, Margerie, Daniel, Ruetten, Hartmut, Schmoll, Dieter, Spranger, Joachim
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2016
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081411/
https://ncbi.nlm.nih.gov/pubmed/27818933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.08.004
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