Transcriptome and chromatin landscape of iNKT cells are shaped by subset differentiation and antigen exposure

Invariant natural killer T cells (iNKT cells) differentiate into thymic and peripheral NKT1, NKT2 and NKT17 subsets. Here we use RNA-seq and ATAC-seq analyses and show iNKT subsets are similar, regardless of tissue location. Lung iNKT cell subsets possess the most distinct location-specific features...

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Udgivet i:Nat Commun
Main Authors: Murray, Mallory Paynich, Engel, Isaac, Seumois, Grégory, Herrera-De la Mata, Sara, Rosales, Sandy Lucette, Sethi, Ashu, Logandha Ramamoorthy Premlal, Ashmitaa, Seo, Goo-Young, Greenbaum, Jason, Vijayanand, Pandurangan, Scott-Browne, James P., Kronenberg, Mitchell
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933435/
https://ncbi.nlm.nih.gov/pubmed/33664261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21574-w
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