SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer

Alternative splicing is a critical process to generate protein diversity. However, whether and how alternative splicing regulates autophagy remains largely elusive. Here we systematically identify the splicing factor SRSF1 as an autophagy suppressor. Specifically, SRSF1 inhibits autophagosome format...

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Gepubliceerd in:Signal Transduct Target Ther
Hoofdauteurs: Lv, Yuesheng, Zhang, Wenjing, Zhao, Jinyao, Sun, Bing, Qi, Yangfan, Ji, Haoyu, Chen, Chaoqun, Zhang, Jinrui, Sheng, Junxiu, Wang, Taishu, Dominguez, Daniel, Liu, Han, Liu, Quentin, Meng, Songshu, Li, Xiaoling, Wang, Yang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933324/
https://ncbi.nlm.nih.gov/pubmed/33664238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-021-00495-6
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