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SRSF1 modulates PTPMT1 alternative splicing to regulate lung cancer cell radioresistance

BACKGROUND: Radioresistance is the major cause of cancer treatment failure. Additionally, splicing dysregulation plays critical roles in tumorigenesis. However, the involvement of alternative splicing in resistance of cancer cells to radiotherapy remains elusive. We sought to investigate the key rol...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Sheng, Junxiu, Zhao, Qingzhi, Zhao, Jinyao, Zhang, Wenjing, Sun, Yu, Qin, Pan, Lv, Yuesheng, Bai, Lu, Yang, Quan, Chen, Lei, Qi, Yangfan, Zhang, Ge, Zhang, Lin, Gu, Chundong, Deng, Xiaoqin, Liu, Han, Meng, Songshu, Gu, Hong, Liu, Quentin, Coulson, Judy M., Li, Xiaoling, Sun, Bing, Wang, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6306353/
https://ncbi.nlm.nih.gov/pubmed/30429088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.11.007
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