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Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells

Cardiac differentiation of embryonic stem cells (ESCs) can give rise to de novo chamber cardiomyocytes and nodal pacemaker cells. Compared with our understanding of direct differentiation toward atrial and ventricular myocytes, the mechanisms for nodal pacemaker cell commitment are not well understo...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Liang, Wenbin, Han, Pengcheng, Kim, Elizabeth H., Mak, Jordan, Zhang, Rui, Torrente, Angelo G., Goldhaber, Joshua I., Marbán, Eduardo, Cho, Hee Cheol
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7932048/
https://ncbi.nlm.nih.gov/pubmed/31648393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3106
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