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Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells

Cardiac differentiation of embryonic stem cells (ESCs) can give rise to de novo chamber cardiomyocytes and nodal pacemaker cells. Compared with our understanding of direct differentiation toward atrial and ventricular myocytes, the mechanisms for nodal pacemaker cell commitment are not well understo...

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Vydáno v:Stem Cells
Hlavní autoři: Liang, Wenbin, Han, Pengcheng, Kim, Elizabeth H., Mak, Jordan, Zhang, Rui, Torrente, Angelo G., Goldhaber, Joshua I., Marbán, Eduardo, Cho, Hee Cheol
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7932048/
https://ncbi.nlm.nih.gov/pubmed/31648393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3106
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