SHOX2 Overexpression Favors Differentiation of Embryonic Stem Cells into Cardiac Pacemaker Cells, Improving Biological Pacing Ability

When pluripotency factors are removed, embryonic stem cells (ESCs) undergo spontaneous differentiation, which, among other lineages, also gives rise to cardiac sublineages, including chamber cardiomyocytes and pacemaker cells. Such heterogeneity complicates the use of ESC-derived heart cells in ther...

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Pubblicato in:Stem Cell Reports
Autori principali: Ionta, Vittoria, Liang, Wenbin, Kim, Elizabeth H., Rafie, Reza, Giacomello, Alessandro, Marbán, Eduardo, Cho, Hee Cheol
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297875/
https://ncbi.nlm.nih.gov/pubmed/25533636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.11.004
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