SHOX2 Overexpression Favors Differentiation of Embryonic Stem Cells into Cardiac Pacemaker Cells, Improving Biological Pacing Ability

When pluripotency factors are removed, embryonic stem cells (ESCs) undergo spontaneous differentiation, which, among other lineages, also gives rise to cardiac sublineages, including chamber cardiomyocytes and pacemaker cells. Such heterogeneity complicates the use of ESC-derived heart cells in ther...

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I publikationen:Stem Cell Reports
Huvudupphovsmän: Ionta, Vittoria, Liang, Wenbin, Kim, Elizabeth H., Rafie, Reza, Giacomello, Alessandro, Marbán, Eduardo, Cho, Hee Cheol
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297875/
https://ncbi.nlm.nih.gov/pubmed/25533636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.11.004
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