SHOX2 Overexpression Favors Differentiation of Embryonic Stem Cells into Cardiac Pacemaker Cells, Improving Biological Pacing Ability

When pluripotency factors are removed, embryonic stem cells (ESCs) undergo spontaneous differentiation, which, among other lineages, also gives rise to cardiac sublineages, including chamber cardiomyocytes and pacemaker cells. Such heterogeneity complicates the use of ESC-derived heart cells in ther...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Ionta, Vittoria, Liang, Wenbin, Kim, Elizabeth H., Rafie, Reza, Giacomello, Alessandro, Marbán, Eduardo, Cho, Hee Cheol
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297875/
https://ncbi.nlm.nih.gov/pubmed/25533636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.11.004
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