Loss of the Epigenetic Mark, 5-hmC, in Psoriasis: Implications for Epidermal Stem Cell Dysregulation

Epigenetic regulation has profound influence on stem cell fate during normal development in maintenance of physiologic tissue homeostasis. Here we report diminished ten-eleven translocation (TET) methylcytosine dioxygenase expression and loss of the DNA hydroxymethylation mark, 5-hydroxymethylcytosi...

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Vydáno v:J Invest Dermatol
Hlavní autoři: Li, Feng, Yuan, Christine W., Xu, Shuyun, Zu, Tingjian, Woappi, Yvon, Lee, Catherine A. A., Abarzua, Phammela, Wells, Michael, Ramsey, Matthew R., Frank, Natasha Y., Wu, Xunwei, Mandinova, Anna, Frank, Markus H., Lian, Christine G., Murphy, George F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7931370/
https://ncbi.nlm.nih.gov/pubmed/31837302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2019.10.016
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