Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability

Synthetic lethality between poly(ADP-ribose) polymerase (PARP) inhibition and BRCA deficiency is exploited to treat breast and ovarian tumors. However, resistance to PARP inhibitors (PARPi) is common. To identify potential resistance mechanisms, we performed a genome-wide RNAi screen in BRCA2-defici...

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I publikationen:Sci Signal
Huvudupphovsmän: Kharat, Suhas S., Ding, Xia, Swaminathan, Divya, Suresh, Akshey, Singh, Manish, Sengodan, Satheesh K., Burkett, Sandra, Marks, Hanna, Pamala, Chinmayi, He, Yafeng, Fox, Stephen D., Buehler, Eugen C., Muegge, Kathrin, Martin, Scott E., Sharan, Shyam K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7575062/
https://ncbi.nlm.nih.gov/pubmed/32817374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aba8091
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