Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study

Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist be...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Valentini, Elisabetta, Zampieri, Michele, Malavolta, Marco, Bacalini, Maria Giulia, Calabrese, Roberta, Guastafierro, Tiziana, Reale, Anna, Franceschi, Claudio, Hervonen, Antti, Koller, Bernhard, Bernhardt, Jürgen, Slagboom, P. Eline, Toussaint, Olivier, Sikora, Ewa, Gonos, Efstathios S., Breusing, Nicolle, Grune, Tilman, Jansen, Eugène, Dollé, Martijn E.T., Moreno-Villanueva, María, Sindlinger, Thilo, Bürkle, Alexander, Ciccarone, Fabio, Caiafa, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076444/
https://ncbi.nlm.nih.gov/pubmed/27587280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101022
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