Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction

BACKGROUND: Physiological disturbances in cortical network excitability and plasticity are established and widespread in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those harbouring the C9ORF72 repeat expansion (C9ORF72(RE)) mutation – the most common ge...

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Pubblicato in:Mol Neurodegener
Autori principali: Perkins, Emma M., Burr, Karen, Banerjee, Poulomi, Mehta, Arpan R., Dando, Owen, Selvaraj, Bhuvaneish T., Suminaite, Daumante, Nanda, Jyoti, Henstridge, Christopher M., Gillingwater, Thomas H., Hardingham, Giles E., Wyllie, David J. A., Chandran, Siddharthan, Livesey, Matthew R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7931347/
https://ncbi.nlm.nih.gov/pubmed/33663561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00433-8
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