Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction

BACKGROUND: Physiological disturbances in cortical network excitability and plasticity are established and widespread in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those harbouring the C9ORF72 repeat expansion (C9ORF72(RE)) mutation – the most common ge...

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Vydáno v:Mol Neurodegener
Hlavní autoři: Perkins, Emma M., Burr, Karen, Banerjee, Poulomi, Mehta, Arpan R., Dando, Owen, Selvaraj, Bhuvaneish T., Suminaite, Daumante, Nanda, Jyoti, Henstridge, Christopher M., Gillingwater, Thomas H., Hardingham, Giles E., Wyllie, David J. A., Chandran, Siddharthan, Livesey, Matthew R.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7931347/
https://ncbi.nlm.nih.gov/pubmed/33663561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00433-8
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