Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction

BACKGROUND: Physiological disturbances in cortical network excitability and plasticity are established and widespread in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients, including those harbouring the C9ORF72 repeat expansion (C9ORF72(RE)) mutation – the most common ge...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Perkins, Emma M., Burr, Karen, Banerjee, Poulomi, Mehta, Arpan R., Dando, Owen, Selvaraj, Bhuvaneish T., Suminaite, Daumante, Nanda, Jyoti, Henstridge, Christopher M., Gillingwater, Thomas H., Hardingham, Giles E., Wyllie, David J. A., Chandran, Siddharthan, Livesey, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7931347/
https://ncbi.nlm.nih.gov/pubmed/33663561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-021-00433-8
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