Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis

Background and Purpose: Activation of hepatic stellate cells (HSC) is a central driver of liver fibrosis. 5-lipoxygenase (5-LO) is the key enzyme that catalyzes arachidonic acid into leukotrienes. In this study, we examined the role of 5-LO in HSC activation and liver fibrosis. Main Methods: Culture...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Front Pharmacol
Hlavní autoři: Pu, Shiyun, Li, Yanping, Liu, Qinhui, Zhang, Xu, Chen, Lei, Li, Rui, Zhang, Jinhang, Wu, Tong, Tang, Qin, Yang, Xuping, Zhang, Zijing, Huang, Ya, Kuang, Jiangying, Li, Hong, Zou, Min, Jiang, Wei, He, Jinhan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930623/
https://ncbi.nlm.nih.gov/pubmed/33679410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.628583
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky