Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis

Background and Purpose: Activation of hepatic stellate cells (HSC) is a central driver of liver fibrosis. 5-lipoxygenase (5-LO) is the key enzyme that catalyzes arachidonic acid into leukotrienes. In this study, we examined the role of 5-LO in HSC activation and liver fibrosis. Main Methods: Culture...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Pu, Shiyun, Li, Yanping, Liu, Qinhui, Zhang, Xu, Chen, Lei, Li, Rui, Zhang, Jinhang, Wu, Tong, Tang, Qin, Yang, Xuping, Zhang, Zijing, Huang, Ya, Kuang, Jiangying, Li, Hong, Zou, Min, Jiang, Wei, He, Jinhan
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930623/
https://ncbi.nlm.nih.gov/pubmed/33679410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.628583
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