Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway

Activating beige adipocytes in white adipose tissue (WAT) to increase energy expenditure is a promising strategy to combat obesity. We identified that mesencephalic astrocyte–derived neurotrophic factor (Manf) is a feeding-induced hepatokine. Liver-specific Manf overexpression protected mice against...

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Detaylı Bibliyografya
Yayımlandı:J Exp Med
Asıl Yazarlar: Wu, Tong, Liu, Qinhui, Li, Yanping, Li, Hong, Chen, Lei, Yang, Xuping, Tang, Qin, Pu, Shiyun, Kuang, Jiangying, Li, Rui, Huang, Ya, Zhang, Jinhang, Zhang, Zijing, Zhou, Jian, Huang, Cuiyuan, Zhang, Guorong, Zhao, Yingnan, Zou, Min, Jiang, Wei, Mo, Li, He, Jinhan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Rockefeller University Press 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054200/
https://ncbi.nlm.nih.gov/pubmed/33856409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20201203
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