Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis

OBJECTIVE: The aim of this study was to investigate whether the nuclear receptor farnesoid X receptor (FXR) could regulate FNDC5/Irisin expression and the role of Irisin in hyperlipidemia and atherosclerosis in ApoE-/- mice. METHODS AND RESULTS: We treated primary human hepatocytes, HepG2 cells, and...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Li, Hong, Shen, Jing, Wu, Tong, Kuang, Jiangying, Liu, Qinhui, Cheng, Shihai, Pu, Shiyun, Chen, Lei, Li, Rui, Li, Yanping, Zou, Min, Zhang, Zhiyong, Jiang, Wei, Qu, Aijuan, He, Jinhan
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546903/
https://ncbi.nlm.nih.gov/pubmed/31191305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00548
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