Mixed micelles loaded with the 5-benzylidenethiazolidine-2,4-dione derivative SKLB023 for efficient treatment of non-alcoholic steatohepatitis

Background: SKLB023, a novel 5-benzylidenethiazolidine-2,4-dione based-derivative, specifically inhibits inducible nitric oxide synthase and shows promise for treating non-alcoholic steatohepatitis (NASH). However, its poor water solubility and low bioavailability limits its clinical use. Here the d...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Li, Yanping, Zhang, Ting, Liu, Qinhui, Zhang, Jinhang, Li, Rui, Pu, Shiyun, Wu, Tong, Ma, Liang, He, Jinhan
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551597/
https://ncbi.nlm.nih.gov/pubmed/31239664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S202821
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