Loss of 5‐lipoxygenase activity protects mice against paracetamol‐induced liver toxicity

BACKGROUND AND PURPOSE: Paracetamol (acetaminophen) is the most widely used over‐the‐counter analgesic and overdosing with paracetamol is the leading cause of hospital admission for acute liver failure. 5‐Lipoxygenase (5‐LO) catalyses arachidonic acid to form LTs, which lead to inflammation and oxid...

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Detaylı Bibliyografya
Yayımlandı:Br J Pharmacol
Asıl Yazarlar: Pu, Shiyun, Ren, Lin, Liu, Qinhui, Kuang, Jiangying, Shen, Jing, Cheng, Shihai, Zhang, Yuwei, Jiang, Wei, Zhang, Zhiyong, Jiang, Changtao, He, Jinhan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2015
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813378/
https://ncbi.nlm.nih.gov/pubmed/26398229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13336
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