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Loss of 5‐lipoxygenase activity protects mice against paracetamol‐induced liver toxicity
BACKGROUND AND PURPOSE: Paracetamol (acetaminophen) is the most widely used over‐the‐counter analgesic and overdosing with paracetamol is the leading cause of hospital admission for acute liver failure. 5‐Lipoxygenase (5‐LO) catalyses arachidonic acid to form LTs, which lead to inflammation and oxid...
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| Pubblicato in: | Br J Pharmacol |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4813378/ https://ncbi.nlm.nih.gov/pubmed/26398229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13336 |
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