NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice

Nuclear receptor coactivator 4 (NCOA4) promotes ferritin degradation and Ncoa4-ko mice in a C57BL/6 background show microcytosis and mild anemia, aggravated by iron deficiency. To understand tissue-specific contributions of NCOA4-mediated ferritinophagy we explored the effect of Ncoa4 genetic ablati...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Haematologica
Prif Awduron: Nai, Antonella, Lidonnici, Maria Rosa, Federico, Giorgia, Pettinato, Mariateresa, Olivari, Violante, Carrillo, Federica, Crich, Simonetta Geninatti, Ferrari, Giuliana, Camaschella, Clara, Silvestri, Laura, Carlomagno, Francesca
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Fondazione Ferrata Storti 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7928015/
https://ncbi.nlm.nih.gov/pubmed/32107334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.241232
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