New Amides Containing Selenium as Potent Leishmanicidal Agents Targeting Trypanothione Reductase

Two new series of 28 selenocyanate and diselenide derivatives containing amide moieties were designed, synthesized, and evaluated for their leishmanicidal activity against Leishmania infantum axenic amastigotes, and selectivity was assessed in human THP-1 cells. Eleven compounds exhibited excellent...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Etxebeste-Mitxeltorena, Mikel, Plano, Daniel, Espuelas, Socorro, Moreno, Esther, Aydillo, Carlos, Jiménez-Ruiz, Antonio, Soriano, Juan Carlos García, Sanmartín, Carmen
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2020
Teme:
Chemistry; Biosynthesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7927869/
https://ncbi.nlm.nih.gov/pubmed/33046492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00524-20
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