Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase

Visceral leishmaniasis caused by Leishmania infantum and Leishmania donovani is one of the neglected tropical diseases (NTDs) caused by trypanosomatids with treatment options limited to outdated drugs often causing adverse effects and promoting drug resistance. Previous antileishmanial drug discover...

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Autors principals:	Julia Andrés-Rodríguez, María-Cristina González-Montero, Nerea García-Fernández, Juan-José Galano-Frutos, Maria-Cristina de Rosa, Patricia Ferreira, María-Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Carlos García-Estrada
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-08-01
Col·lecció:	International Journal for Parasitology: Drugs and Drug Resistance
Matèries:	Leishmania donovani Visceral leishmaniasis Cyclic nitrofurans Trypanothione Trypanothione reductase Molecular docking
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211320725000284
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