Mechanistic, in-silico and in vitro studies with nitrofurans reveal potent leishmanicidal activity and inhibition of trypanothione reductase

Visceral leishmaniasis caused by Leishmania infantum and Leishmania donovani is one of the neglected tropical diseases (NTDs) caused by trypanosomatids with treatment options limited to outdated drugs often causing adverse effects and promoting drug resistance. Previous antileishmanial drug discover...

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Hlavní autoři:	Julia Andrés-Rodríguez, María-Cristina González-Montero, Nerea García-Fernández, Juan-José Galano-Frutos, Maria-Cristina de Rosa, Patricia Ferreira, María-Yolanda Pérez-Pertejo, Rosa M. Reguera, Rafael Balaña-Fouce, Carlos García-Estrada
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-08-01
Edice:	International Journal for Parasitology: Drugs and Drug Resistance
Témata:	Leishmania donovani Visceral leishmaniasis Cyclic nitrofurans Trypanothione Trypanothione reductase Molecular docking
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2211320725000284
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