Low-Dose Decitabine Inhibits Cytotoxic T Lymphocytes-Mediated Platelet Destruction via Modulating PD-1 Methylation in Immune Thrombocytopenia

Cytotoxic T lymphocytes (CTLs)-mediated platelet destruction plays an important role in the pathogenesis of primary immune thrombocytopenia (ITP). The programmed cell death protein 1 (PD-1) signaling can turn off autoreactive T cells and induce peripheral tolerance. Herein, we found that the express...

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Vydáno v:Front Immunol
Hlavní autoři: Han, Panpan, Yu, Tianshu, Hou, Yu, Zhao, Yajing, Liu, Yang, Sun, Yunqi, Wang, Haoyi, Xu, Pengcheng, Li, Guosheng, Sun, Tao, Hu, Xiang, Liu, Xinguang, Li, Lizhen, Peng, Jun, Zhou, Hai, Hou, Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7925841/
https://ncbi.nlm.nih.gov/pubmed/33679776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.630693
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