Indirubin modulates CD4(+) T‐cell homeostasis via PD1/PTEN/AKT signalling pathway in immune thrombocytopenia

Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by an immune mediated decrease in platelet number. Disturbance of CD4(+) T‐cell homeostasis with simultaneous decrease of CD4(+)CD25(+)Foxp3(+ )regulatory T cells (Tregs) as well as unrestricted proliferation and activatio...

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Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Zhao, Yajing, Han, Panpan, Liu, Lei, Wang, Xiaojie, Xu, Pengcheng, Wang, Haoyi, Yu, Tianshu, Sun, Yunqi, Li, Lizhen, Sun, Tao, Liu, Xinguang, Zhou, Hai, Qiu, Jihua, Wang, Liang, Peng, Jun, Xu, Shuqian, Hou, Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378207/
https://ncbi.nlm.nih.gov/pubmed/30609280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14089
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